The team behind the Oxford Covid jab has created a vaccine that could "revolutionise" cancer treatment.
The jab will be tested in humans for the first time after promising results in animal experiments.
The cancer vaccine was combined with another existing therapy that turns a person’s immune system against cancer.
The two together were able to shrink tumours in mice and even improve their survival rates.
The first human trial will involve 80 patients diagnosed with non-small cell lung cancer – one of the most common and serious types of cancer in the UK, dignosed in 47,000 people every year.
Professor Adrian Hill, director of the Jenner Institute at the university, said: "This new vaccine platform has the potential to revolutionise cancer treatment."
The jab is based on the same “viral vector” technology that was used in the Oxford-AstraZeneca Covid-19 jab.
With the Covid vaccine, genetic material is transported to a person’s cells within a harmless common cold virus in a bid to train the immune system to fight off the actual virus.
The team developed their two-dose cancer vaccine also using viral vectors, one of which is the same as the vector in the Oxford-AstraZeneca jab.
Genetic material prompts the body to respond to molecules called MAGE proteins, which are found on the surface of cancer cells.
Most read in The Sun
New evidence about chief Maddie suspect leaves investigators 'shocked'
Adele's destroyed God knows how many dream trips by fans, says Piers Morgan
Tributes to mum killed by ex as driver who run over knifeman praised as hero
Coleen Nolan's new man seen for first time on TV as fans say the same thing
Benoit Van den Eynde, professor of tumour immunology at the University of Oxford, said: "We knew that MAGE-type proteins act like red flags on the surface of cancer cells to attract immune cells that destroy tumours.
"Importantly for target specificity, MAGE-type antigens are not present on the surface of normal tissues, which reduces the risk of side effects caused by the immune system attacking healthy cells."
The vaccine is given alongside immunotherapy – a type of treatment that wakes up the patient’s own immune system and arms it to fight a tumour.
Immunotherapy has given astounding results in cancer treatment. However, some patients do not have enough T-cells in their immune system to fight the tumour.
The cancer vaccine is able to boost T-cells, enhancing the immunotherapy, the mouse studies showed.
It comes as a study has shown that the Oxford Covid jab, given to 25million Brits, is the best at keeping people with the virus out of hospital.
As well as generating virus-busting antibodies, the vaccine also creates “training camps” in the body for search-and-destroy T-cells which can kill even new variants.
It means the body can continue making these vital cells long after the antibodies have waned – and possibly for life.
We pay for your stories!
Do you have a story for The Sun news desk?
Email us at [email protected] or call 02077824104. You can WhatsApp us on 07423 720 250. We pay for videos too. Click here to upload yours
Click here to get The Sun newspaper delivered for FREE for the next six weeks.
Source: Read Full Article